Characterization and evaluation of a novel silver nanoparticles-loaded polymethyl methacrylate denture base: <i>In vitro</i> and <i>in vivo</i> animal study

The aim of this study was to optimize the preparation method polymethyl methacrylate (PMMA) denture base loaded with nano silver (NAg), more effectively and safely impart sustainable antibacterial functions. NAg solution synthetized mixed acrylic acid methyl methyacrylate (MMA) monomer in order prepare a new type (NS)/polymer specimens (NS/PMMA). surface morphology, mechanical strength, antimicrobial activity, anti-aging performance, cytotoxicity biocompatibility NS/PMMA were evaluated comparison fabricated using traditional adding methods NAg-free base. aesthetic characteristics strength met clinical application requirements. Meanwhile, showed better properties, no displayed exceptional biocompatibility. thus has great potential for application.